Journal article
Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome
D Ait Ouakrim, SGH Dashti, R Chau, DD Buchanan, M Clendenning, C Rosty, IM Winship, JP Young, GG Giles, B Leggett, FA Macrae, DJ Ahnen, G Casey, S Gallinger, RW Haile, L Le Marchand, SN Thibodeau, NM Lindor, PA Newcomb, JD Potter Show all
Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2015
DOI: 10.1093/jnci/djv170
Abstract
© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. BACKGROUND: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers. The aim of this study was to determine whether use of aspirin and ibuprofen in a nontrial setting is associated with the risk of colorectal cancer risk for MMR gene mutation carriers.METHODS: We included 1858 part..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by grant UM1 CA167551 from the National Cancer Institute, National Institutes of Health (NIH), and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators. Collaborating centers include Australasian Colorectal Cancer Family Registry (U01/U24 CA097735), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794), Stanford Consortium Colorectal Cancer Family Registry (U01/U24 CA074799), and University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806). This work was also supported by Centre for Research Excellence grant APP1042021 and program grant APP1074383 from the National Health and Medical Research Council (NHMRC), Australia. AKW is a NHMRC Early Career Fellow. MAJ is an NHMRC Senior Research Fellow. JLH is a NHMRC Senior Principal Research Fellow. DDB is a University of Melbourne Research at Melbourne Accelerator Program (R@MAP) Senior Research Fellow. CR is the Jeremy Jass Pathology Fellow.